Targeted Particle Delivery in Arrhythmia Patients

Pawan Kumar Pandey and Malay Das
Indian Institute of Technology Kanpur


Present work involves a numerical simulation and study of targeted particle delivery in cerebral artery with saccular aneurysm. Primary objective is to determine particle release map (PRM). PRM becomes useful in determination of catheter injection position and particle injection waveform. Blood flow simulations are done using a finite volume method based solver. For simulations a realistic three dimensional tortuous artery with mesh of tetrahedron cells is used. To mimic the behavior of blood, Carreau-Yasuda model is used for viscosity values. Simulations are done initially for steady cases and then used as initial solution for pulsatile flow simulation. An artificially developed inlet flow waveform is used. The waveform mimics the changes in pulsation of blood flow in Arrhythmia patients. Results are reported for three different waveforms corresponding to three different arrhythmic flow pattern. Analysis of PRM shows fragmented patches of suitable locations with stretched shape. Suitable locations are less than 30% for steady cases and reduce even further for pulsatile waveforms with less than 50% target site missed particles. Suitable locations shrink with increase in the vortex structures at three dimensional twist and bends. PRM shapes vary with time hence intermittent particle release pattern is recommended to reduce the systemic toxicity.