Multi-feature Probabilistic Detector Applied on Apnea/hypopnea Monitoring



Robust, real-time apnea and hypopnea detection for sleep apnea syndrome (SAS) patients monitoring still represents a major challenge due to noise artifacts, the complexity of respiration patterns and inter-subject discrepancies. We propose in this study the application of an original multi-feature probabilistic detector (MFPD) for SAS monitoring.

Only the breathing waveform (nasal airflow) is used to derive a set of respiration features (vari- ance, mobility, peak-to-peak amplitude and total respiration cycle), and a binary detection probability is updated from a centralized fusion using the Kullback-Leibler divergence (KLD). As a key in the feature statistic learning process, the KLD tracks the separability of the event-vs-no-event distributions of each feature. While the optimal feature set selection lies beyond the scope of our study, we illustrate however the ability to adapt each feature’s weight dynamically in the fusion.

The detector is under test for 43 severe OSA patients undergoing a full PSG sampled at 1024Hz. True positive events are defined as less than 10 sec before or within the annotated events (including both apnea and hypopnea), other detections are noted as false positives while true negatives are those annotated events without corresponding detections in the same ranges. A total of 4240 events are annotated, while each recording file constitutes an independent test since feature statistic learning is performed as per recording based on past apnea/hypopnea detections as explained in the above. The online detection performances suggest promising sensitivity and ppv for bedside longterm monitoring and event-based therapies.