Evaluation of Diastolic Heart Function using Echocardiography and Pulse Wave Analysis in patients after anthracycline therapy.

Magdaléna Šudáková, Ksenia Budinskaya, Zuzana Nováková
Masarykova univerzita


Introduction Diastolic dysfunction plays a crucial role in heart failure. In clinical practice, the standard cardiac examination is echocardiography, where pulse Doppler analysis is used to evaluate diastolic function. The similar parameters could be measured by applanation tonometry. The aim of this study was to determine the correlation between the parameters of diastolic heart function measured by echocardiography and obtained by pulse wave analysis. Methods The study included 92 subjects (41 females) who had been previously treated with anthracycline antibiotics.
Pulse waves were registered by the applanation tonometry (Sphygmocor; AtCor Medical, Australia). Each measurement being calibrated by oscillometric method of blood pressure measurement (Omron HEM-907-E instrument, Japan). From the pulse wave we obtained the values of systolic pressure (SBP) and diastolic pressure (DBP), Tension-Time Index (TTI), Diastolic Time Index (DTI) and Subendocardial Viability Ratio (SEVR). With echocardiographic examination (Nemio XG, TOSHIBA, Japan) were estimated parameters of diastolic heart function: E - mitral peak early diastolic filling velocity, A - peak left ventricular filling during atrial contraction, E / A - the ratio of the velocity E a A in left ventricle, IRT - isovolumic relaxation time, DT - deceleration time. Results All measured values were in the physiological range. We found a statistically significant correlation between IRT and DTI, between A, E / A and SEVR. We did not find a significant correlation between the parameters of diastolic function and age or time since the end of treatment. Conclusion From the observed correlation between echocardiography and applanation tonometry, we can assume that the SEVR parameter is suitable for the assessment of diastolic heart function. Acknowledgement: This study was supported by Specific University Research Grant no. MUNI/A/1246/2020 provided by the Ministry of Education, Youth, and Sports of the Czech Republic.